Lorazepam (Ativan)


Lorazepam (Ativan)


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What is Lorazepam (Ativan)?

Lorazepam (Ativan) belongs to the class of medications called benzodiazepines. It is used for the fast relief of the symptoms of the anxiety. This medication has an action that slows down communication between nerve cells in the brain (ie, the central nervous system).

Some people experience an improvement in their level of anxiety within 30 minutes after taking lorazepam. In injectable solution, lorazepam can be used as initial treatment in the control of successive epileptic seizures (status epilepticus).

Your doctor may have suggested this medicine for a condition not listed in this drug information article. In addition, some forms of this medicine might not be used for all the disorders mentioned in this article. If you have not discussed this with your doctor, or if you are not sure why you are taking this medicine, check it out. Do not stop taking this medicine without first consulting your doctor.

Do not give this medicine to anyone, even someone who has the same symptoms as yours. This medication may be harmful to people for whom it has not been prescribed.


Lorazepam (Ativan) is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension associated with the

The effectiveness of Lorazepam (Ativan) in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.


Lorazepam (Ativan) is administered orally. For optimal results, dose, frequency of administration, and duration of therapy should be individualized according to patient response. To facilitate this, 0.5 mg, 1 mg, and 2 mg tablets are available.

The usual range is 2 to 6 mg/day given in divided doses, the largest dose being taken before bedtime, but the daily dosage may vary from 1 to 10 mg/day.

For anxiety, most patients require an initial dose of 2 to 3 mg/day given b.i.d. or t.i.d.

For insomnia due to anxiety or transient situational stress, a single daily dose of 2 to 4 mg may be given, usually at bedtime.

For elderly or debilitated patients, an initial dosage of 1 to 2 mg/day in divided doses is recommended, to be adjusted as needed and tolerated.

The dosage of Lorazepam (Ativan) should be increased gradually when needed to help avoid adverse effects. When higher dosage is indicated, the evening dose should be increased before the daytime doses.

side effects of Lorazepam (Ativan)?

Many medications can cause side effects. A side effect is an undesirable response to a drug when taken at normal doses. It can be mild or severe, temporary or permanent. The side effects listed below are not felt by everyone who takes this medicine.If side effects worry you, discuss the risks and benefits of this medication with your doctor.

At least 1% of people taking this medicine have reported the following side effects. A lot of these side effects can be taken care of and a few can go away on their own with time.

A minus 1% of this medicine have been reported after the side effects below. A lot of side effects can be taken care of and a few can go away over time.

Consult your doctor if you experience side effects and if they are serious or bothersome. Your pharmacist may be able to give you advice on what to do if these side effects occur:

clumsiness or unsteady gait;
dizziness or lightheadedness
speech difficulties.
Most of the side effects are not very often, but they have been generating serious problems if you have not consulted them.

Check with your doctor earlier if any of the following side effects occur:

disturbances of thought (of disorientation, irrational convictions, or lost of sense of reality);
behavioral changes (eg, aggression, tantrums)
blurred vision or other impaired vision
changes in appetite
changes in sex drive or sexual ability
dryness of the mouth
a false sense of well-being;
fast, irregular heartbeat
salivation accumulates;
memory problems;
muscle spasms;
muscle weakness
nausea or vomiting
urinary problems;
concealed brightening or bruising
an inexperienced excitement, a state of nervousness or irritability;
inexperienced fatigue or weakness;
yellowing of the whites of the eyes or skin.


The benzodiazepines, including Ativan (lorazepam), produce increased CNS-depressant effects when administered with other CNS depressants such as alcohol, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressantsnarcotic analgesics, sedative antihistamines, anticonvulsants, and anesthetics.

Concomitant use of clozapine and lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest.

Concurrent administration of lorazepam with valproate results in increased plasma concentrations and reduced clearance of lorazepam. Lorazepam dosage should be reduced to approximately 50% when coadministered with valproate.

Concurrent administration of lorazepam with probenecid may result in a more rapid onset or prolonged effect of lorazepam due to increased half-life and decreased total clearance. Lorazepam dosage needs to be reduced by approximately 50% when coadministered with probenecid.

The effects of probenecid and valproate on lorazepam may be due to inhibition of glucuronidation.

Administration of theophylline or aminophylline may reduce the sedative effects of benzodiazepines, including lorazepam.

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